Anti Wrinkle Cream
Although no one will judge and love you by your wrinkles and even if you prefer not to worship the Altar of Eternal Youth, it can be sweeter to postpone their appearance, have a healthier skin and age gracefully.
Are there effective ways to actually postpone and reduce fine lines and wrinkles and have smoother and healthier skin?
To give a positive answer to this question without hype lets examine the real reason why wrinkles form in the first place.
Why premature wrinkles form?
Cutaneous ageing is triggered by several internal and external factors that by repeated actions lead to the appearance of wrinkles and sagging skin.
The human skin matrix is made up of ingredients like collagen, elastin, the base membrane, and water holding molecules with names that include the Greek term ‘glyco’ for sugar or carbohydrates: the proteoglycans and glycosaminoglycans.
Collagen and elastin are the skin tissues responsible for keeping skin firm and stretchable.
Proteoglycans and Glycosaminoglycans are sugar chains or carbohydrate complex molecules linked to proteins or free standing and are responsible for binding and holding water within the skin. This hydration from within contributes to skin’s elasticity and resilience.
As skin ages, both intrinsically and through photoaging (solar radiation damage), signs of aging start to show up on the skin. The production of critical fibers and water holding molecules is naturally reduced as people age. In addition to skin cells getting old and thinner, the foundation of the extracellular matrix deteriorates as well, making the skin seem dryer, weaker, less elastic and to start rippling and losing its flexibility and stamina.
There are some little things you can do daily to avoid premature skin aging. Genetics play into the problem as can cigarettes, applying sunblock, and even facial mannerisms. Cutting back on cigarettes and protecting yourself from harmful sun exposure can help reduce premature skin aging and symptoms of photoaging.
Wrinkle Culprits and Wrinkle Correctors for Less Wrinkled Skin
UV radiation is one of the principle factors in cellular death and premature skin aging. Photo damage results in wrinkling, loss of thickness, increased fragility and premature aging. The changes in the skin are normally slow but persistent and begin to take place already at doses of UV-irradiation that do not show up as redness on the outside. The damage is therefore hardly noticeable in the early stages. The UV-provoked induction of collagen degradation is derived from collagenase enzymes that are released in excess by skin cells like keratinocytes or fibroblasts. This is part of a natural defense reaction of the cells.
In general, inflammatory skin disorders can increase the action of collagenase enzymes in the skin but it is also known that excessive collagenase causes irritation and inflammation. Research groups have documented these mechanisms many times. Since small inflammations happen very regularly or they are permanently present, the labor of collagenase enzymes gets out of balance and affects the breakdown of connective tissue and the development of hyaluronidases, enzymes that corrupt hyaluronic acid (also known as hyaluronan or HA), one of the most abundant glycosaminoglycans in the skin makeup.
Hyaluronic acid is a major component of the extracellular matrix and plays an important role in tissue repair. It is present in a variety of body tissues including the skin, eyes, synovial fluid of joints, and many other parts of the body. Hyaluronan is a carbohydrate consisting of alternating units of D-glucuronic acid and N-acetyl-D-glucosamine arranged in chains. In its natural form it is hydrophilic and can absorb large quantities of water to maintain tissue hydration levels.
Hyaluronan is implicated in the normal wound healing process, which comprises a series of sequential events including inflammation, granulation, re-epithelialization, and remodelling. In the early stages of wound healing, levels of hyaluronan are high and decline thereafter due to the effects of hyaluronidase.
The degradation or destruction of collagen and hyaluronic acid results in the signs of skin aging, visible in the formation of wrinkles and decreasing elasticity.
By arousing the hydrolysis of hyaluronic acid, a polysaccharide that is a major element of the interstitial barrier, hyaluronidase diminishes the viscosity of hyaluronic acid, thereby increasing tissue permeability which increases the likelihood of allergens penetrating the skin barrier, delayed wound healing.
As people get older, the skin becomes jumbled. Communication and cellular synchronization are no longer functioning like they used to at a younger age. These disruptions modify the functioning of the skin, which does not play its role as a barrier organ anymore.
Overview of skin
Skin has two basic parts:
- Epidermis – Outer most layer of skin – Very thin – Approximately 100 microns
- Dermis – Bottom layer of skin – Much thicker – Approximately 1000 microns (10 x thicker than epidermis)
- Outer most protective “Shell”/”Armor”/”Crust”
- “ Basal” cells at bottom of layer produce new cells and push these new cells to the surface
Kids – 5 day cell cycle / 20 year old – 30 days / 40 year old – 40 days… etc.
- As cells near the surface, they become “squamous” (flattened) and start producing high amounts of keratin – same hard substance as in our fingernails, important protection from abrasion.
- At the surface the cells die, and leave a thick layer of dead cells filled with keratin – like a “crust” – encasing our body. (Water proof barrier.)
- The slower the epidermal cell cycle, the thicker the crust will become. Thus kids have radiant skin, while adult skin dulls with age.
- Keratin layer is variable in thickness, color, texture.
- Causes unevenness in texture and color of skin.
- Causes “dullness”, roughness, fine lines and wrinkles.
The Epidermis also contains melanocytes
- Melanocytes produce melanin, the pigment in our skin which makes us albino, white, yellow, brown or black, depending on how much melanin is present.
- Melanocytes are stimulated by sun exposure to produce melanin, which gives us a temporary tan. This melanin absorbs sun light thus protecting deeper tissues.
- Due to a variety of factors, melanocytes can produce too much melanin:
- Age – Age Spots/Liver Spots
- Sun Damage – Sun Spots/Solar Lentigos
- Hormone Fluctuations – Melasma
- Trauma – Post Traumatic Hyper-Pigmentation
- Genetics – Freckles
- Thick layer of structural tissue, primarily collagen (made by Fibroblast cells)
- Laid down in layer after layer, like a tight basket weave
- Gives skin Tone / Stretchiness / Resilience / Firmness / Smoothness
- Contains vasculature – blood supply (no vasculature in epidermis) and many other types of cells – see diagram
- With age, Fibroblasts tire out and produce less and less collagen
- Dermis becomes progressively thinner and thinner (even “paper” thin)
- Because old collagen is not being replaced with new collagen, the old collagen degrades, deteriorates, layers lose their tight basket weave, get tangled (“gnarled”), causing deep wrinkles
- Loses it’s Tone / Stretchiness / Resilience / Firmness / Smoothness / pores enlarge
- Excessive Laxity and Sagging / Wrinkles / Baggy / “Hangs on Bones” Look
Now that we have identified the reasons why skin sags and loses tone, the issue becomes how to take action and prevent the normal drooping and sagging of aging skin.
A good deal of the solution is in the last place we had ever looked.
Helix Aspersa Müller Glycoconjugates An Advanced Anti-Aging Serum
The Helix Aspersa Müller snails, like all snails, live their lives constantly exposed to UV rays, environmental stress, and other factors, just like we humans do. Snails have the amazing ability to naturally produce a biological serum inside their cells that acts as a defensive mechanism against damage. The interesting aspect of this for us humans is that this same serum possesses characteristics similar to that of the reaction that human fibroblasts undergo when damaged. The snail secretion is now highly sought after since it can prompt growth factors in human skin and even help control the skin’s own innate response to injury or stress .
The snail’s protective secretion supports the innate immune system performance of the snail and hence according to scientific limitations, it is a serum composed of hyaluronic acid and other glycosaminoglycans, proteoglycans, enzymes, low molecular weight compounds that act as antioxidants in a way similar to vitamins, high molecular weight molecules that act as oxygen couriers and oligoelements some of which act as coenzymes. Experts characterize this protective liquid as a complex of glycoconjugates that performs as a natural serum: a watery animal fluid rich in proteins, carbohydrates and oligoelements that can be used to transfer immunity from one individual to another individual.
Skin elasticity and skin tone also enhanced by application of glycosaminoglycans.
Researchers studying the snail secretion have noted that topical application of glycosaminoglycans and proteoglycans can prompt the development of elastin in the skin matrix. ( McGowan SE, Liu R, Harvey CS. Effects of heparin and other glycosaminoglycans on elastin production by cultured neonatal rat lung fibroblasts. Arch. Biochem. Biophys. 1993; 302: 322-331). This is possible because the basement membrane proteins influence collagen and elastin production through up-regulated genes.
It is worth noting that in the dermis, the elastic fibres form a network which contributes to the elasticity of the skin and accordingly to its firmness and tone. Elastin is the major component of these fibers, and is initially synthesized by the fibroblasts in the form of a soluble polypeptide: tropoelastin. The formation of elastic microfibrils then takes place via intramolecular bonds, called desmosines, between the lysine residues of the polypeptide chains. These bonds confer the necessary insolubility to elastin fibers.
Snail serum offers an effective cosmetic “solution” to premature signs of aging
You can now avoid signs of photoaging and skin sagging using the snail serum because the elements go straight to work on the principle causes of why wrinkles and fine lines form in the first place.
You now have an anti-aging serum that will help skin by:
- Improving skin resistance and flexibility
- Increasing the transmission of the intra and intercellular communication messengers of natural skin repair
- Activating and regulating skin micro-circulation, thereby increasing skin vitality
- Guarding against external attacks by ensuring epidermis symmetry in spite of the presence of deleterious agents contained in industrial and urban pollution.
- Improving cutaneous moisturizing and keeps hydration stable
- Re-establishing the hydrolipidic film
- Fighting free radicals
BIOSKINCARE Anti Aging Shield for Active People in Polluted Cities
Powered by BIOCUTIS® Serum
No Side Effect
60 Days Money Back Guarantee
50 grams = 1.76 oz $69.98
Save at least 20% off price & save on domestic or world wide shipping costs
when you order more than one month’s supply.
Discount Price Two Bottles: $55.98 each, at checkout within our secure shopping cart.
BIOSKINCARE is a new anti-aging product that, when absorbed by the skin, works biologically to stop the damaging effects of collagenases and hyaluronidases, photo damage, and other factors that breakdown collagen, elastin, and water holding molecules. As an anti-aging product, BIOSKINCARE is revolutionizing the way people restore collagen and elastin synthesis and elevate moisture content in the skin.
BIOSKINCARE can help you strengthen your own skin by promoting skin unity between two important structures: desmosomes and cytokeratins.
Desmosomes are junction structures joining keratinocytes together by a calcium-dependent phenomenon. They are regularly compared with press studs, desmosomes work to guarantee unity and inter and intra cellular communication.
Cytokeratins are specific proteins that make up the essential part of the keratinocytes cytoskeleton and take part in their organization. The structure of the cytokeratin is tied directly to the strength of the layers of skin.
Cell Cohesion and Cell Communication Enhanced by Bio-Available Calcium within the Skin
One of the most important elements in any organism is calcium. It makes up a large part of the organisms skeleton and plays a role in cellular communication. Calcium is a main ingredient in skin: it takes part in tissues cohesion and in cell synchronization. Cytokeratins proliferation and desmosomes formation are highly dependent on calcium but this depends upon calcium bioavailability i.e. mildly metabolized by cells. Skin aging is triggered by the natural reduction of calcium bioavailability.
Our special anti-wrinkle product, embodied in BIOSKINCARE, boosts calcium fixation by keratinocytes in human skin in very much the same way it does it for the snail’s skin and the renewal of its shell when flawed, and thus yields the following benefits:
- Make skin healthier and stronger by triggering the proliferation of cytokeratins and desmosomes.
- Make it easier for cells to communicate amongst themselves.
- Stability against environmental factors. This guarantees epidermal unity in spite of the presence of alarming agents contained in industrial pollution.
It is possible to improve communication between keratinocytes and improve cellular cohesion. The strength of skin is revived. The skin is more resistant and perfectly acts as a protection barrier against external aggressions.
Protection of the skin against degrading enzymes and activation of enzymes that degrade damaged tissues
The serum regulates the enzymes and acts as an anti-elastase and anti-collagenase to prevent the degradation of collagen and elastin. It protects the skin against dermis proteases (elastases, collagenases and hyaluronidases), and in particular against the loss of collagen when affected by UV rays and collagenases. It works biologically to stop the early onset of wrinkles, loss of elasticity and photoaging.
BIOSKINCARE can also stimulate cells and reduce fundamental synthesis. Collagen and elastin production is sparked when the biological ingredient in our cream is absorbed by the skin. The remodeling of collagen and elastin, vital skin elements, bolsters the skin, making sagging less likely.
The serum not only promotes the rejuvenation of collagen and elastin but also the formation of glycomolecules. The serum helps develop water holding molecules from deep within. These molecules have significant water binding and holding capacity. The role of these molecules is important in rejuvenating skin and preventing overstretching.
BIOSKINCARE Helps to Fight Against Free Radicals
During its normal lifecycle, skin cells get older, thinner, and begin to lose moisture, losing their flexibility and resolve. The destruction of cells and the loss of fibroblasts depends on a few different factors . They are intensified by external factors, such as UV rays, which initiate free radical development.
Free radicals are atoms or clumps of atoms or molecules with a single electron on an external orbital creating a high instability and therefore a high reactivity. Free radicals are harmful reagents able to destabilize other elements which could lead to cellular death and destruction. For instance, a super oxide contains highly reactive oxygen focusing on:
- Proteins, exposed to polymerization and inactivation,
- Membranous lipids with the formation of other peroxides (malonaldehyde or MDA),
- DNA alterations and mutations.
The formation of free radicals in human skin is inevitable. Skin appears older due to the constant development of free radicals (the production of free radicals varies according to the way of life and environment).
The immune serum also acts as blocker of free radical development by stopping the growth of super oxide ions. The antioxidant qualities in BIOSKINCARE complement its efficacy in activating the synthesis of collagen, elastin and glycosaminoglycans and make it a perfect anti wrinkle cream that can halt free radical progression and the signs of premature skin aging.
Powered by BIOCUTIS® Serum
No Side Effects
60 Days Money Back Guarantee
BIOSKINREJUVENATION – the easy way to get healthier skin, a more even color tone, and a brighter complexion
50 grams = 1.76 oz $79.98
Save on domestic or world wide shipping costs
when you order more than one month’s supply.
Discount Price Two Bottles: $69.98 each, at checkout within our secure shopping cart.
- Anti Aging Shield For Skin
- Reduces Appearance of Wrinkles
- Retards Photo-Aging
- Clears Actinic Keratosis Crusts
- Prevents Actinic Keratosis
- Powered by BIOCUTIS® Serum
- Supports Your Immune System
- Promotes Quick Skin Healing
- Repairs Sun Damaged Skin
- The Most Powerful Antioxidants
- Moisturizes Deep Within The Skin
- Removes Skin Blemishes
- No Side Effects
- Money Back Guarantee
Ingredients in BIOSKINCARE
- Distilled Water (solvent)
- Peg-4 Olivate (emulsifier derived from Olive Oil)
- Sorbitan Olivate from Olive Oil (moisturizer)
- Squalane from Olive Oil (natural moisturizer and antioxidant)
- Hyaluronic Acid (in solution – moisturizer)
- Biocutis® Serum: Helix Aspersa Müller Glycoconjugates
- Glycerin (humectant)
- SUPRAPEIN™, a synergistic combination of botanical extracts that yields a natural preservative with a broad-spectrum of antimicrobial activity.