Enzymes – Miracles of the Complex Molecules That Rule Our Biology
BIOCUTIS® Serum contains proteins that are highly soluble in aqueous solutions. They act as enzymes and signal transduction proteins.
Through the metabolic processes enzymes (all enzymes are proteins) are capable of quickly reducing the swelling or edema of traumatized or injured tissues by actually “digesting” or breaking down damaged tissues and ruptured cells at the site of lesions, allowing these waste materials to be removed quickly from skin lesions so as to reduce inflammation and subsequent pain, speeding the healing process and encouraging regeneration of tissues.
In biology, signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. Such processes take place in as little time as a millisecond or as long as a few seconds.
The human body can sustain a variety of injuries, including penetrating trauma, burn trauma and blunt trauma. All of these insults set into motion an orderly sequence of events that are involved in the healing response, in which the normal functional tissue (skin) is replaced by connective tissue (scar) and the healing response is characterized by the movement of specialized cells into the wound site.
Healing is the complex and dynamic process that results in the restoration of anatomical continuity and function. There are four basic responses that can occur following an injury: Normal repair (reestablished equilibrium), is the response where there is a re-established equilibrium between scar formation and scar remodeling. Excessive healing (fibrosis and contractures), there is too much deposition of connective tissue that results in altered structure and thus loss of function. Deficient healing (chronic ulcers) is the opposite of fibrosis; it exists when there is insufficient deposition of connective tissue matrix and the tissue is weakened and fragile to the point where it can bruise and bleed easily.
We can classify scars into Mayor and Minor scars. As mayor scars we include burn scars, keloids and hypertrophic scars. As minor scars we include atrophic scars (e.g. stretch marks), sun related scars and general damage to skin texture and physiology such as sun related (e.g. actinic keratosis, age spots, and wrinkles) and finally minor scarring such as what we find in razor bumps, ingrown hair picking and others conditions.
Gentle home exfoliation by the action of enzymes to reduce scars
BIOCUTIS® brings to you the ONLY skin renewal products that incorporate natural skin renewal activators and biological enzymes that gently dissolve or “digest” the damaged or worn out cells while at the same time triggers the proliferation of fibroblasts that give rise to new connective tissues and hydrating molecules within the skin: new collagen and elastin cells and glycosaminoglycans and proteoglycans. The result is a coordinated biological regulation of the skin renewal process and thus healthy skin and advanced skin rejuvenation.
The beauty and genius of nature’s most complete and balanced biological skin revival serum is that it works by creating an equivalent of a NON TRAUMA exfoliation which means that your skin will react to the messenger molecules and the enzymes that recognize and degrade damaged cells and non functional tissues by activating its own biological response modifiers thereby supporting your body’s immune system and repair mechanisms to treat skin injuries (cuts, bruises, abrasions, acne lesions, scars, wounds, burns), dysfunctional tissues (keratosis, keloid and hypertrophic scars, excess dryness) and prevent over reactions that further destroy tissues and immune-mediated inflammatory skin disorders (inflammatory acne, rosacea, eczema and most dermatitis reactions).
And it will do so in an environment that has also been provided with all the molecule messengers that are necessary for a) the recognition of those cells and tissues that are damaged and need to be “digested” by the enzymes and b) an orchestrated regeneration or biosynthesis of new healthy tissues and with antioxidants that limit damage from free radical generation from the cells that participate in the immune system and create them to fight invading microbes.
When the enzymes “digest” or dissolve the topmost micron of skin (part of the outer layer that is no thicker than a sheet of paper, slowly and over a period of time) unlike all other such methods as glycolic acid peels, dermabrasion or laser resurfacing, there is no heat and blistering, so there is nothing to heal.
When you burn your skin, your body creates healing protein like collagen and elastin bands, pus, melanin, water, and antibodies (inflamm-aging) that rush to the aid of the trauma. In that case, there actually IS a burn to tend to…
However, during your BIOCUTIS® skin treatment, there is NOT any burn or trauma repair. The proteins that transport the repair elements to the epidermis and underlying stratum corneum are flooded with your own molecules and DNA. The new skin growth that is waiting to be exposed is not only smoother and tighter on its own, but it has just been soaked with those reparation proteins and water holding molecules that hydrated your skin and flooded to the surface to come to the aid of the ‘NON TRAUMA EXFOLIATION’.
For hard, rough and old scars clinical trials have shown that the best results from chemical, physical exfoliation or laser treatments is achieved when the treatment is combined with SKIN REGENERATING ACTIVATORS. The reason is after the skin has been damaged by exfoliators it is IMPERATIVE that skin healing progresses at a quick pace.
Skin healing is a highly ordered systemic process that involves the coordinated regulation of cell proliferation and migration, and tissue remodeling .
Skin Exfoliation usually only involves removal of dead skin cells. BIOCUTIS® skin products are unlike any other exfoliation treatment available today because they include the only system that gently exfoliates with ENZYMES & NATURAL SKIN RENEWAL ACTIVATORS that signal your system to get rid of damaged skin cells and target the cells that play the biggest role in keeping skin young, the fibroblasts, which are deep down in the mesoderm (middle layer) and stimulate them to reproduce all the structural components of healthy skin. And the whole process is coordinated at the pace needed to restore a healthy and beautiful skin naturally.
The Skin Renewal Activators are natural skin regenerating peptides and glycomolecules that signal your body to accelerate skin renewal . The same molecules are found in healthy human skin when it is wounded. They coordinate and regulate cell proliferation and migration and tissue remodeling. But as we age these regulatory growth factors slow down their activity and it is necessary to supply them topically to achieve the same skin renewal achieved by youngsters.
Reaching the Fibroblasts
The point is enzymes help the peptides and glyco messengers to reach the fibroblasts. Skin is not fragile but admirably tough, more a barrier than a membrane. That’s why the outer (and toughest) layer, the stratum corneum, is also called the horny layer. It’s about ten microns thick -a lot in the dermatology world- and consists of layers of the same dead cells (corneocytes) that compose fingernails. The horny layer is often compared to a brick-and-mortar construction: The large cells of the epidermis are packed tightly together, while the small spaces between them are filled with fats (lipids). The design is foolproof: The corneocytes keep foreign material out, and the lipids make sure water stays in. The second layer (the epidermis) is about 80µm micrometres or microns thick. The third layer (the dermis) contains the capillaries and nerve endings and is several millimeters thick.
A micrometre is one-millionth of a metre – one-thousandth of a millimetre. One micron is about a tenth of the diameter of a droplet of mist or fog. It can be written in scientific notation as 1×10−6 m, meaning 1 / 1,000,000 m.
Yet it’s on this hard ground that most products are meant to work. Most skin-care products focus on moisturizing the ‘dead’ layer of the skin, the 10 microns or so that require water so they don’t feel dry, but that is not enough and in most cases it is deleterious for it ends wetting the skin too much.
The combination of tough stratum corneum layer and live epidermis makes it extremely difficult for external substances to penetrate skin. Traditionally, only small water-soluble molecules are able to diffuse slowly into the skin. Physical exfoliation of 10 or so microns, specially of rough scar tissues helps active ingredients to penetrate more easily the outer layer of the skin into the epidermis and the basal layer, while they also polish the surface and make it softer and look and feel more even. If scars are new and damage to skin is minor, or for routine exfoliation the action of the enzymes in our products is best.
Natural Skin Care Products with the Benefits of Enzymes
BIOCUTIS® skin care products have a two fold effect: (1) Degrade debris, damaged, abnormal and necrotic tissues & decongest the skin as they helps to dissolve all damaged structures into their amino-acid and other components by the action of enzymes and makes them available for use in rebuilding healthy skin. (2) Favors tissue regeneration.
BIOCUTIS® skin products leave your skin smooth, refreshed, soft and with use over a period of time they nourishe the skin, fight free radicals and signs of aging and reduce all types of scars and blemishes: acne, scars, keratosis bumps, razor nicks and burns, actinic keratosis lesions, roughness, dryness, eczema, dermatitis, the effects on the skin of radiotherapy for cancer, blisters, scrapes, cuts, and the list can go on and on. Our skin products clear and enhance your complexion and operate as your best routine skin care for a lifetime of healthy skin and graceful again.
Antioxidant Enzymes in Skin Care
Scientists using new computer technologies are gaining insight into the three-dimensional structure of some of the body’s key proteins. At the forefront of this new frontier is one of these proteins–the enzyme superoxide dismutase (SOD) present in the BIOCUTIS® serum, and famous for preventing oxygen toxicity in the body and thought to hamper such diverse disorders as heart disease, cancer, Alzheimer’s disease and the aging process.
The scientists have already uncovered a complex scenario in which the enzyme lures and traps the superoxide molecule, which it is programmed to destroy.
http://articles.latimes.com/1988-12-26/local/me-599_1_proteins-superoxide-dismutase-three-dimensional-structure.
Enzymes are necessary for your body to function. Anything you do, whether its eating, sleeping or simply living, enzymes are there working behind the scenes, making life happen. Enzymes are found in every living cell, of every organic life-form. Whether the organism is a vegetable, animal or a human being, there is no life without the existence of enzymes. Due to the work of enzymes, grass grows, seeds sprout, flowers bloom, beer and wine ferment, and even leaves change colors in the autumn.
In a nutshell enzymes are the life-force of every cell, they start chemical reactions, or make those chemical reactions run faster. The word enzyme is derived from the Greek word, enzymos. The definition of enzymos is to be leavened or fermented. The process of fermenting milk or grapes, inspired our ancestors to begin practicing what is known as alchemy, because it was believed that fermentation was the product of some sort of magic. In modern times we know that fermentation is due to enzymes catalyzing milk into cheese. We know that enzymes catalyze every biochemical reaction that occurs within living organism.
The same anti-oxidants anti-inflammatory properties of compounds that are found in green tea, blueberries, and other superfoods are present in BIOCUTIS® serum, and this time specifically geared to the protection and recovery of the skin. The discovery of these new molecules could have massive implications for the development of new medicines to fight various diseases.
Twenty different types of amino acids found in nature are used in protein structure. Actually, depending on the number used and their order, an infinite number of proteins can be made from only these 20 different amino acids. If you compare any protein to a chain, amino acids are the links in the chain. The number of amino acids in different protein types within living things is between 100 and 3,000. Random removal, addition, or changing of the order of just one amino acid in the chain would render the protein completely useless, and in fact harmful.
Along with the location and number of amino acids, the three- dimensional geometry of the protein they form is also extremely important. It’s not enough for the amino acids to be of the right number and in the right place, they also need to fold at certain points to form a shape that lets the protein carry out its duty. To allow these folds to take place, amino acids located at sites to be folded are joined by much weaker bonds, which facilitates folding at the right angle. If this weren’t so and all amino acid bonds were of equal strength, the protein formed would be straight, without function-in fact, useless.
In short, a protein’s three-dimensional shape is highly important. Only because of their 3-D shape can enzymes in particular direct, regulate, and accelerate many reactions. Even if the protein possessed the right number of amino acids in the correct order, its lack of correct geometric shape would render it useless. In order to facilitate folding, the bonds of attraction between amino acids need to be individually regulated with incredible control and sensitivity. Even the slightest detail must be determined with care.
Since the formation of even one protein molecule requires so many processes and controls, today’s technology has not been able to synthesize a protein molecule under laboratory conditions.
Enzymes in Skin Care Products
Many complex events take place in our bodies every second. So detailed are they, that at every step, their complex reactions need to be regulated by super overseers to bring about order: the enzymes. In every living cell, hundreds of enzymes are found, each with its own special duty: breakdown of nutrients, production of energy from nutrients, production of macromolecular chains from simple molecules, and innumerable other similar processes.
Enzymes play a vital role in all cellular functions, from protein synthesis to energy production. If not for these enzymes, not one of your bodily functions, from the simplest to the most complex, would operate; or else they would slow down and stop altogether. You would not be able to breathe, eat or digest anything, see, or speak. The result in either case would be death.
We can compare enzymes’ speeding-up of body processes to an example from everyday life. The few seconds’ time it takes to read a sentence under normal circumstances would, without any enzymes, take ten years. The enzymes that play a role in bodily reactions are at least as rapid as this example.
The relationship between an enzyme and the substance it affects is like that between a lock and key. An enzyme and the substance it binds to, join together in a complex three-dimensional manner (see Figure 5.3). Each has been created to fit the other in the most appropriate ways. What’s more, this harmony comes about at a speed so dizzying that in one second, one enzyme can bind to 300 substances, one after the after, changing each one into the desired form and then separating from it .
In short, cells live thanks to enzymes, and each cell produces the enzymes it needs for itself, in the required amounts.
Hormones
Multicellular organisms like animals and humans are composed of cells that have different structures and functions. The body depends on these cells’ complex yet highly cooperative functions. The 100 trillion cells in the human body work together as if they all know each other. To the end, they carry out the functions assigned to them without any neglect or laziness. And within this perfect coordination are messenger chemicals called hormones, whose function is to carry orders between cells. The growth and internal balance of the body, control of reproduction, coordination of the nervous system, and many other processes are realized because of the messages carried by hormones to the relevant cells. Without you even knowing it, a superb command system is at work, as an unseen intelligence sends its orders to cells throughout your body.
This superior intelligence keeps everything under control without you even knowing it. You do not have any say in this system. For instance, you cannot make your body grow as much as you want, no matter how much you may wish so. Whatever you do, you cannot order your cells to divide, multiply and make you grow. Only your cells know the pre-determined height and shape for your body. They will multiply until they reach that target and then stop growing, at just the right time.
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