Hyperpigmentation, Melasma, Skin Discoloration Treatment

The cream includes a human growth factor peptide, (nonapeptide 1) derived from the melanocyte-stimulating-hormone (MSH). It blocks melanin synthesis and reduces the formation of unwanted pigmentation, allowing control over skin tone, blotches and dark spots.

Melanocyte Stimulating Hormone (MSH) is a peptide hormone produced by the pituitary gland. When your body is exposed to sunlight MSH is produced to stimulate production and release of melanin (melanogenesis) by melanocytes in skin and hair.

The ingredient in the cream is a biomimetic peptide that takes the place of the natural ligand (alpha-MSH) on its specific receptor (MC1-R) and then blocks the melanin synthesis.

Peptides are made up of individual amino acids that are linked together like a pearl necklace. These are differentiated into oligopeptides (2-10 amino acids) and polypeptides (10-100 amino acids).

Biomimetic peptides are identical to the skin’s peptides. They act on the physiological mechanisms of the skin with a high specificity. Oligopeptides and polypeptides fulfill important tasks as hormones (peptide hormone) or as neurotransmitters or neuromodulators (neuropeptides).

Skin pigmentation and tanning are related to the amount and distribution of melanin in epidermal melanosomes. The epidermis cell population includes keratinocytes and the melanocytes that supply the keratinocytes with melanosomes, i.e., melanin containing pigment granules, via dendritic processes. Melanin is a dark pigment that is produced by the oxidation of tyrosine to dopa and dopaquinone by the enzyme tyrosinase, to produce compounds that polymerize to form melanin.

Ingredients that inhibit tyrosinase enzyme activity are derived from plants that are native to the northern Canadian prairie region. Rumex extracts are included which are capable of inhibiting the production of the enzyme tyrosinase, leading to clearer complexion and a reduction in skin pigmentation. They do this by limiting both melanin production (tan) and skin reddening (erythema). Visible signs of color reduction in age spots are observed after 3 weeks.

Our product regulates pigmentation tone for the total skin surface, lightening the complexion, and blocking the deleterious effects on the appearance caused by certain endocrine disorders. And it is a safe product for achieving such regulation of epidermal pigmentation tone. It helps with a number of localized hyperpigmentation disorders. These include pigmented spots such as freckles, solar lentigines (also called liver spots), acanthosis nigricans (a hypermelanotic disorder), cafe-au-lait spots, moles, and melasma (localized post-partum darkening of the skin).

Is Melasma and Hyperpigmentation a Threat to Your Skin’s Health?

The answer is no, it may not be pretty, but hyperpigmentation is usually harmless. Overactive skin cells called melanocytes, which stimulate the production of melanin, the substance that gives your skin color, cause this common condition.

What causes those melanocytes to misbehave?

The sun, for one thing, as well as hormones and certain diseases and medications. Here’s an overview of the different types of hyperpigmentation disorders.

1. Solar radiation

Exposure to UV rays plays a significant role in developing hyperpigmentation. The sun on the skin stimulates melanocytes to produce more melanin so that they absorb the ultraviolet rays, thus helping to protect skin from overexposure to UV rays. As the level of melanin increases, skin begins to darken or tan. But when melanocytes overdo it and trigger the production of too much melanin, the result is hyperpigmentation, typically in the form of freckles or large “age spots.” New dark spots can pop up and/or existing ones can darken.

How can you avoid them?

By limiting sun exposure, wearing protective clothing, and using a broad spectrum, water-resistant sunscreen with a minimum SPF of 15 (though 30 or higher offers protection for a longer period of time).

2. Post Inflammatory Hyperpigmentation

Have you noticed how your skin sometimes darkens after an injury, such as a cut, burn, scrape, or pimple?

The discoloration can last for weeks, months, or even years and turn into a permanent scar. This type of hyperpigmentation can occur with any skin type but is especially common among people whose skin has more color — not just dark skin but light brown and olive skin as well.

What Can You Do About It?

Sunscreen helps to prevent postinflammatory hyperpigmentation and keeps the area from darkening further. If the discoloration really bothers you, you can use a skin lightener, chemical peel, microdermabrasion or BIOSKINREJUVENATION to treat the darkened spot.

3. Melasma or the Mask of Pregnancy

Melasma is a common hyperpigmentation disorder that affects mostly women. (According to the American Academy of Dermatology, only 10 percent of people affected by melasma are men.) The actual cause of melasma is unknown, but experts believe the condition is hereditary. Sometimes called the mask of pregnancy, melasma causes brown or grayish-brown patches to appear on the cheeks, nose, and forehead.

The culprit is hormones, which fluctuate wildly during pregnancy. Other melasma-triggering factors include birth control pills, hormone therapy, certain medications or cosmetics, and the sun.

Melasma usually fades on its own, either after childbirth or once you stop taking hormones or birth control pills. But if discolored skin does not lighten, treat the area with BIOSKINREJUVENATION, chemical peels, microdermabrasion, or laser treatments.

4. Hyperpigmentation due to an illness or compromised health condition

Skin hyperpigmentation can be a symptom of an underlying medical condition such as Addison’s disease, a rare endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Or it can be a result of interaction between ultraviolet light and certain medications. Some known medications that can cause skin pigmentation include antimalarial medications, antiseizure medications, and minocycline.

If you’ve got questions or you’re concerned about any skin changes, consult your internist or dermatologist. Remember, it is much better to play safe and prevent than be sorry.

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  BIOSKINREJUVENATION

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